Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

Kai Qiao, Xin Yuan, Li Wan, Ming Wei Zheng, Dong Zhang, Bing Bing Fan, Zhe Chen Di, Zheng Fang, Kai Guo

科研成果: 期刊稿件文章同行评审

18 引用 (Scopus)

摘要

A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.

源语言英语
页(从-至)5789-5793
页数5
期刊Green Chemistry
19
24
DOI
出版状态已出版 - 2017

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