Indium(III) iodide-mediated Strecker reaction in water: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation

Zhi Liang Shen; Shun Jun Ji; Teck Peng Loh

doi:10.1016/j.tet.2008.06.047

Indium(III) iodide-mediated Strecker reaction in water: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation

Zhi Liang Shen, Shun Jun Ji, Teck Peng Loh

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.

Original language	English
Pages (from-to)	8159-8163
Number of pages	5
Journal	Tetrahedron
Volume	64
Issue number	35
DOIs	https://doi.org/10.1016/j.tet.2008.06.047
State	Published - 25 Aug 2008
Externally published	Yes

Keywords

Indium(III) iodide
Strecker reaction
Three-component reaction
Water
α-Aminonitrile

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10.1016/j.tet.2008.06.047

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abstract = "A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.",

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author = "Shen, {Zhi Liang} and Ji, {Shun Jun} and Loh, {Teck Peng}",

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T2 - an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation

AU - Shen, Zhi Liang

AU - Ji, Shun Jun

AU - Loh, Teck Peng

PY - 2008/8/25

Y1 - 2008/8/25

N2 - A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.

AB - A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.

KW - Indium(III) iodide

KW - Strecker reaction

KW - Three-component reaction

KW - Water

KW - α-Aminonitrile

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U2 - 10.1016/j.tet.2008.06.047

DO - 10.1016/j.tet.2008.06.047

M3 - 文章

AN - SCOPUS:47049127635

SN - 0040-4020

VL - 64

SP - 8159

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JO - Tetrahedron

JF - Tetrahedron

IS - 35

ER -

Indium(III) iodide-mediated Strecker reaction in water: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation

Abstract

Keywords

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