Insight into a direct solid-solid transformation: A potential approach for the removal of residual solvents

Pengpeng Yang; Chenguang Lin; Wei Zhuang; Qingshi Wen; Fengxia Zou; Jingwei Zhou; Jinglan Wu; Hanjie Ying

doi:10.1039/c6ce00034g

Insight into a direct solid-solid transformation: A potential approach for the removal of residual solvents

Pengpeng Yang, Chenguang Lin, Wei Zhuang, Qingshi Wen, Fengxia Zou, Jingwei Zhou, Jinglan Wu, Hanjie Ying

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Here we report two new crystal forms of adenosine 3′,5′-cyclic monophosphate sodium and the discovery of the direct solid-solid transformation process from its methanol trihydrate (solvate) to its pentahydrate form (hydrate) that is only mediated by humidity. These findings provide a potential approach for the removal of residual solvents in the manufacturing of pharmaceuticals and food additives.

Original language	English
Pages (from-to)	1699-1704
Number of pages	6
Journal	CrystEngComm
Volume	18
Issue number	10
DOIs	https://doi.org/10.1039/c6ce00034g
State	Published - 2016

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abstract = "Here we report two new crystal forms of adenosine 3′,5′-cyclic monophosphate sodium and the discovery of the direct solid-solid transformation process from its methanol trihydrate (solvate) to its pentahydrate form (hydrate) that is only mediated by humidity. These findings provide a potential approach for the removal of residual solvents in the manufacturing of pharmaceuticals and food additives.",

author = "Pengpeng Yang and Chenguang Lin and Wei Zhuang and Qingshi Wen and Fengxia Zou and Jingwei Zhou and Jinglan Wu and Hanjie Ying",

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T2 - A potential approach for the removal of residual solvents

AU - Yang, Pengpeng

AU - Lin, Chenguang

AU - Zhuang, Wei

AU - Wen, Qingshi

AU - Zou, Fengxia

AU - Zhou, Jingwei

AU - Wu, Jinglan

AU - Ying, Hanjie

PY - 2016

Y1 - 2016

N2 - Here we report two new crystal forms of adenosine 3′,5′-cyclic monophosphate sodium and the discovery of the direct solid-solid transformation process from its methanol trihydrate (solvate) to its pentahydrate form (hydrate) that is only mediated by humidity. These findings provide a potential approach for the removal of residual solvents in the manufacturing of pharmaceuticals and food additives.

AB - Here we report two new crystal forms of adenosine 3′,5′-cyclic monophosphate sodium and the discovery of the direct solid-solid transformation process from its methanol trihydrate (solvate) to its pentahydrate form (hydrate) that is only mediated by humidity. These findings provide a potential approach for the removal of residual solvents in the manufacturing of pharmaceuticals and food additives.

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DO - 10.1039/c6ce00034g

M3 - 文章

AN - SCOPUS:84959537416

SN - 1466-8033

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SP - 1699

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JO - CrystEngComm

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ER -

Insight into a direct solid-solid transformation: A potential approach for the removal of residual solvents

Abstract

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