Intracellular glutathione detection using MnO 2-nanosheet- modified upconversion nanoparticles

Renren Deng; Xiaoji Xie; Marc Vendrell; Young Tae Chang; Xiaogang Liu

doi:10.1021/ja2100774

Intracellular glutathione detection using MnO ₂-nanosheet- modified upconversion nanoparticles

Renren Deng, Xiaoji Xie, Marc Vendrell, Young Tae Chang, Xiaogang Liu

Research output: Contribution to journal › Article › peer-review

877 Scopus citations

Abstract

We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO ₂) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO ₂ into Mn ²⁺. The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.

Original language	English
Pages (from-to)	20168-20171
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	50
DOIs	https://doi.org/10.1021/ja2100774
State	Published - 21 Dec 2011
Externally published	Yes

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abstract = "We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO 2) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO 2 into Mn 2+. The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.",

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AU - Liu, Xiaogang

PY - 2011/12/21

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AB - We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO 2) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO 2 into Mn 2+. The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.

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Intracellular glutathione detection using MnO ₂-nanosheet- modified upconversion nanoparticles

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