Intracellular glutathione detection using MnO 2-nanosheet- modified upconversion nanoparticles

Renren Deng; Xiaoji Xie; Marc Vendrell; Young Tae Chang; Xiaogang Liu

doi:10.1021/ja2100774

Intracellular glutathione detection using MnO ₂-nanosheet- modified upconversion nanoparticles

Renren Deng, Xiaoji Xie, Marc Vendrell, Young Tae Chang, Xiaogang Liu

科研成果: 期刊稿件 › 文章 › 同行评审

867 引用（Scopus）

摘要

We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO ₂) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO ₂ into Mn ²⁺. The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.

源语言	英语
页（从-至）	20168-20171
页数	4
期刊	Journal of the American Chemical Society
卷	133
期	50
DOI	https://doi.org/10.1021/ja2100774
出版状态	已出版 - 21 12月 2011
已对外发布	是

访问文件

10.1021/ja2100774

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{f516905718394fe28090f6a8d6aac4db,

title = "Intracellular glutathione detection using MnO 2-nanosheet- modified upconversion nanoparticles",

abstract = "We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO 2) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO 2 into Mn 2+. The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.",

author = "Renren Deng and Xiaoji Xie and Marc Vendrell and Chang, {Young Tae} and Xiaogang Liu",

year = "2011",

month = dec,

day = "21",

doi = "10.1021/ja2100774",

language = "英语",

volume = "133",

pages = "20168--20171",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "50",

}

TY - JOUR

T1 - Intracellular glutathione detection using MnO 2-nanosheet- modified upconversion nanoparticles

AU - Deng, Renren

AU - Xie, Xiaoji

AU - Vendrell, Marc

AU - Chang, Young Tae

AU - Liu, Xiaogang

PY - 2011/12/21

Y1 - 2011/12/21

N2 - We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO 2) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO 2 into Mn 2+. The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.

AB - We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO 2) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO 2 into Mn 2+. The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery.

UR - http://www.scopus.com/inward/record.url?scp=83755168195&partnerID=8YFLogxK

U2 - 10.1021/ja2100774

DO - 10.1021/ja2100774

M3 - 文章

C2 - 22107163

AN - SCOPUS:83755168195

SN - 0002-7863

VL - 133

SP - 20168

EP - 20171

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 50

ER -

Intracellular glutathione detection using MnO 2-nanosheet- modified upconversion nanoparticles

摘要

访问文件

其它文件与链接

指纹

引用此

Intracellular glutathione detection using MnO ₂-nanosheet- modified upconversion nanoparticles