Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones

Shichao Ren; Chao Feng; Teck Peng Loh

doi:10.1039/c5ob00632e

Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones

Shichao Ren, Chao Feng, Teck Peng Loh

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122 Scopus citations

Abstract

The Fe^III- or Ag^I-catalyzed oxidative fluorination of cyclopropanols via radical rearrangement is disclosed. This process features a straightforward and highly effective protocol for the site-specific synthesis of β-fluoroketones and represents an expedient method for the synthesis of γ-, δ- and ε-fluoroketones. Notably, this reaction proceeds at room temperature and tolerates a diverse array of cyclopropanols.

Original language	English
Pages (from-to)	5105-5109
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	18
DOIs	https://doi.org/10.1039/c5ob00632e
State	Published - 14 May 2015
Externally published	Yes

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title = "Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones",

abstract = "The FeIII- or AgI-catalyzed oxidative fluorination of cyclopropanols via radical rearrangement is disclosed. This process features a straightforward and highly effective protocol for the site-specific synthesis of β-fluoroketones and represents an expedient method for the synthesis of γ-, δ- and ε-fluoroketones. Notably, this reaction proceeds at room temperature and tolerates a diverse array of cyclopropanols.",

author = "Shichao Ren and Chao Feng and Loh, {Teck Peng}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

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T1 - Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones

AU - Ren, Shichao

AU - Feng, Chao

AU - Loh, Teck Peng

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015/5/14

Y1 - 2015/5/14

N2 - The FeIII- or AgI-catalyzed oxidative fluorination of cyclopropanols via radical rearrangement is disclosed. This process features a straightforward and highly effective protocol for the site-specific synthesis of β-fluoroketones and represents an expedient method for the synthesis of γ-, δ- and ε-fluoroketones. Notably, this reaction proceeds at room temperature and tolerates a diverse array of cyclopropanols.

AB - The FeIII- or AgI-catalyzed oxidative fluorination of cyclopropanols via radical rearrangement is disclosed. This process features a straightforward and highly effective protocol for the site-specific synthesis of β-fluoroketones and represents an expedient method for the synthesis of γ-, δ- and ε-fluoroketones. Notably, this reaction proceeds at room temperature and tolerates a diverse array of cyclopropanols.

UR - http://www.scopus.com/inward/record.url?scp=84928920245&partnerID=8YFLogxK

U2 - 10.1039/c5ob00632e

DO - 10.1039/c5ob00632e

M3 - 文章

C2 - 25866198

AN - SCOPUS:84928920245

SN - 1477-0520

VL - 13

SP - 5105

EP - 5109

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 18

ER -

Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones

Abstract

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