Light-triggered release of lenalidomide with fluorescent indication for inhibition of COX-2 enzyme activity in cancer cells

Ming Liu; Yajing Li; Fang Wang; Sheng Lu; Long Jiang; Xiaoqiang Chen

doi:10.1039/d5cc00695c

Light-triggered release of lenalidomide with fluorescent indication for inhibition of COX-2 enzyme activity in cancer cells

Ming Liu, Yajing Li, Fang Wang, Sheng Lu, Long Jiang, Xiaoqiang Chen

College of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

In this work, we have developed a Sanger's reagent-based photocage, LNDA-NBD-Sanger, which releases the caged COX-2 inhibitor, lenalidomide (LNDA), under 400 nm UV irradiation while producing a fluorescent signal from the activated nitrobenzoxadiazole (NBD) derivative, realizing the monitoring of LNDA release in cancer cells and light-controlled anti-cancer therapy.

Original language	English
Pages (from-to)	6518-6521
Number of pages	4
Journal	Chemical Communications
Volume	61
Issue number	35
DOIs	https://doi.org/10.1039/d5cc00695c
State	Published - 28 Mar 2025

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10.1039/d5cc00695c

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abstract = "In this work, we have developed a Sanger's reagent-based photocage, LNDA-NBD-Sanger, which releases the caged COX-2 inhibitor, lenalidomide (LNDA), under 400 nm UV irradiation while producing a fluorescent signal from the activated nitrobenzoxadiazole (NBD) derivative, realizing the monitoring of LNDA release in cancer cells and light-controlled anti-cancer therapy.",

author = "Ming Liu and Yajing Li and Fang Wang and Sheng Lu and Long Jiang and Xiaoqiang Chen",

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AU - Liu, Ming

AU - Li, Yajing

AU - Wang, Fang

AU - Lu, Sheng

AU - Jiang, Long

AU - Chen, Xiaoqiang

PY - 2025/3/28

Y1 - 2025/3/28

N2 - In this work, we have developed a Sanger's reagent-based photocage, LNDA-NBD-Sanger, which releases the caged COX-2 inhibitor, lenalidomide (LNDA), under 400 nm UV irradiation while producing a fluorescent signal from the activated nitrobenzoxadiazole (NBD) derivative, realizing the monitoring of LNDA release in cancer cells and light-controlled anti-cancer therapy.

AB - In this work, we have developed a Sanger's reagent-based photocage, LNDA-NBD-Sanger, which releases the caged COX-2 inhibitor, lenalidomide (LNDA), under 400 nm UV irradiation while producing a fluorescent signal from the activated nitrobenzoxadiazole (NBD) derivative, realizing the monitoring of LNDA release in cancer cells and light-controlled anti-cancer therapy.

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M3 - 文章

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Light-triggered release of lenalidomide with fluorescent indication for inhibition of COX-2 enzyme activity in cancer cells

Abstract

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