Light-triggered release of lenalidomide with fluorescent indication for inhibition of COX-2 enzyme activity in cancer cells

Ming Liu, Yajing Li, Fang Wang, Sheng Lu, Long Jiang, Xiaoqiang Chen

科研成果: 期刊稿件文章同行评审

摘要

In this work, we have developed a Sanger's reagent-based photocage, LNDA-NBD-Sanger, which releases the caged COX-2 inhibitor, lenalidomide (LNDA), under 400 nm UV irradiation while producing a fluorescent signal from the activated nitrobenzoxadiazole (NBD) derivative, realizing the monitoring of LNDA release in cancer cells and light-controlled anti-cancer therapy.

源语言英语
页(从-至)6518-6521
页数4
期刊Chemical Communications
61
35
DOI
出版状态已出版 - 28 3月 2025

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