Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes

Bing Jiang; Meng Zhao; Shu Sen Li; Yun He Xu; Teck Peng Loh

doi:10.1002/anie.201710601

Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes

Bing Jiang, Meng Zhao, Shu Sen Li, Yun He Xu, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

A Rh^III-catalyzed intramolecular oxidative cross-coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo- and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3-conjugated diene structure.

Original language	English
Pages (from-to)	555-559
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	2
DOIs	https://doi.org/10.1002/anie.201710601
State	Published - 8 Jan 2018

Keywords

C−H activation
cross-coupling
homogeneous catalysis
macrocycles
rhodium

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10.1002/anie.201710601

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abstract = "A RhIII-catalyzed intramolecular oxidative cross-coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo- and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3-conjugated diene structure.",

keywords = "C−H activation, cross-coupling, homogeneous catalysis, macrocycles, rhodium",

author = "Bing Jiang and Meng Zhao and Li, {Shu Sen} and Xu, {Yun He} and Loh, {Teck Peng}",

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AU - Jiang, Bing

AU - Zhao, Meng

AU - Li, Shu Sen

AU - Xu, Yun He

AU - Loh, Teck Peng

PY - 2018/1/8

Y1 - 2018/1/8

N2 - A RhIII-catalyzed intramolecular oxidative cross-coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo- and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3-conjugated diene structure.

AB - A RhIII-catalyzed intramolecular oxidative cross-coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo- and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3-conjugated diene structure.

KW - C−H activation

KW - cross-coupling

KW - homogeneous catalysis

KW - macrocycles

KW - rhodium

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U2 - 10.1002/anie.201710601

DO - 10.1002/anie.201710601

M3 - 文章

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AN - SCOPUS:85042094348

SN - 1433-7851

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 2

ER -

Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes

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Keywords

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