Microfluidic synthesis of pyrrolidin-2-onesviaphotoinduced organocatalyzed cyclization of styrene, α-bromoalkyl esters and primary amines

Minghui Wei; Jingming Zhang; Chengkou Liu; Wei He; Tingyu Wang; Xiaobing Yang; Zhao Yang; Zheng Fang; Kai Guo

doi:10.1039/d1ob01082d

Microfluidic synthesis of pyrrolidin-2-onesviaphotoinduced organocatalyzed cyclization of styrene, α-bromoalkyl esters and primary amines

Minghui Wei, Jingming Zhang, Chengkou Liu, Wei He, Tingyu Wang, Xiaobing Yang, Zhao Yang, Zheng Fang, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A green and efficient reaction route for the synthesis of pyrrolidin-2-onesviaphotoinduced organocatalyzed three-component cyclization of styrene, tertiary α-bromoalkyl esters and primary amines in a microchannel reactor under visible light conditions has been developed. Moreover, the overall process can be carried out under mild conditions without using a metal. In addition, a reasonable reaction mechanism was proposed based on control experiments.

Original language	English
Pages (from-to)	6468-6472
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	19
Issue number	29
DOIs	https://doi.org/10.1039/d1ob01082d
State	Published - 7 Aug 2021

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title = "Microfluidic synthesis of pyrrolidin-2-onesviaphotoinduced organocatalyzed cyclization of styrene, α-bromoalkyl esters and primary amines",

abstract = "A green and efficient reaction route for the synthesis of pyrrolidin-2-onesviaphotoinduced organocatalyzed three-component cyclization of styrene, tertiary α-bromoalkyl esters and primary amines in a microchannel reactor under visible light conditions has been developed. Moreover, the overall process can be carried out under mild conditions without using a metal. In addition, a reasonable reaction mechanism was proposed based on control experiments.",

author = "Minghui Wei and Jingming Zhang and Chengkou Liu and Wei He and Tingyu Wang and Xiaobing Yang and Zhao Yang and Zheng Fang and Kai Guo",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",

year = "2021",

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doi = "10.1039/d1ob01082d",

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TY - JOUR

T1 - Microfluidic synthesis of pyrrolidin-2-onesviaphotoinduced organocatalyzed cyclization of styrene, α-bromoalkyl esters and primary amines

AU - Wei, Minghui

AU - Zhang, Jingming

AU - Liu, Chengkou

AU - He, Wei

AU - Wang, Tingyu

AU - Yang, Xiaobing

AU - Yang, Zhao

AU - Fang, Zheng

AU - Guo, Kai

PY - 2021/8/7

Y1 - 2021/8/7

N2 - A green and efficient reaction route for the synthesis of pyrrolidin-2-onesviaphotoinduced organocatalyzed three-component cyclization of styrene, tertiary α-bromoalkyl esters and primary amines in a microchannel reactor under visible light conditions has been developed. Moreover, the overall process can be carried out under mild conditions without using a metal. In addition, a reasonable reaction mechanism was proposed based on control experiments.

AB - A green and efficient reaction route for the synthesis of pyrrolidin-2-onesviaphotoinduced organocatalyzed three-component cyclization of styrene, tertiary α-bromoalkyl esters and primary amines in a microchannel reactor under visible light conditions has been developed. Moreover, the overall process can be carried out under mild conditions without using a metal. In addition, a reasonable reaction mechanism was proposed based on control experiments.

UR - http://www.scopus.com/inward/record.url?scp=85111435446&partnerID=8YFLogxK

U2 - 10.1039/d1ob01082d

DO - 10.1039/d1ob01082d

M3 - 文章

C2 - 34236379

AN - SCOPUS:85111435446

SN - 1477-0520

VL - 19

SP - 6468

EP - 6472

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 29

ER -

Microfluidic synthesis of pyrrolidin-2-onesviaphotoinduced organocatalyzed cyclization of styrene, α-bromoalkyl esters and primary amines

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