TY - JOUR
T1 - New potential inhibitors of DNA topoisomerase. Part II
T2 - Design and synthesis of α-lapachone derivatives under microwave irradiation
AU - Wei, Ping
AU - Zhang, Xiaohong
AU - Tu, Shujiang
AU - Yan, Shu
AU - Ying, Hanjie
AU - Ouyang, Pingkai
PY - 2009/2/1
Y1 - 2009/2/1
N2 - A new series of potential inhibitors of DNA topoisomerase II were synthesized from facile materials (aromatic aldehydes, Meldrum's acid and 2-hydroxynaphthalene-1,4-dione) under microwave irradiation. The method provides a valuable tool in designing new and more potent cytotoxic analogues. This procedure is advantageous both economically and environmentally.
AB - A new series of potential inhibitors of DNA topoisomerase II were synthesized from facile materials (aromatic aldehydes, Meldrum's acid and 2-hydroxynaphthalene-1,4-dione) under microwave irradiation. The method provides a valuable tool in designing new and more potent cytotoxic analogues. This procedure is advantageous both economically and environmentally.
KW - DNA topoisomerase II
KW - Microwave irradiation
KW - Potential inhibitors
KW - α-Lapachone
UR - http://www.scopus.com/inward/record.url?scp=58549102691&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2008.12.006
DO - 10.1016/j.bmcl.2008.12.006
M3 - 文章
C2 - 19112020
AN - SCOPUS:58549102691
SN - 0960-894X
VL - 19
SP - 828
EP - 830
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 3
ER -