Optimizing Escherichia coli strains and fermentation processes for enhanced L-lysine production: a review

Zijuan Wu, Tianpeng Chen, Wenjun Sun, Yong Chen, Hanjie Ying

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

lysine is an essential amino acid with significant importance, widely used in the food, feed, and pharmaceutical industries. To meet the increasing demand, microbial fermentation has emerged as an effective and sustainable method for L-lysine production. Escherichia coli has become one of the primary microorganisms for industrial L-lysine production due to its rapid growth, ease of genetic manipulation, and high production efficiency. This paper reviews the recent advances in E. coli strain engineering and fermentation process optimization for L-lysine production. Additionally, it discusses potential technological breakthroughs and challenges in E. coli-based L-lysine production, offering directions for future research to support industrial-scale production.

Original languageEnglish
Article number1485624
JournalFrontiers in Microbiology
Volume15
DOIs
StatePublished - 2024

Keywords

  • Escherichia coli
  • L-lysine
  • fermentation optimization
  • genome modification
  • separation and purification

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