TY - JOUR
T1 - Optimizing Escherichia coli strains and fermentation processes for enhanced L-lysine production
T2 - a review
AU - Wu, Zijuan
AU - Chen, Tianpeng
AU - Sun, Wenjun
AU - Chen, Yong
AU - Ying, Hanjie
N1 - Publisher Copyright:
Copyright © 2024 Wu, Chen, Sun, Chen and Ying.
PY - 2024
Y1 - 2024
N2 - lysine is an essential amino acid with significant importance, widely used in the food, feed, and pharmaceutical industries. To meet the increasing demand, microbial fermentation has emerged as an effective and sustainable method for L-lysine production. Escherichia coli has become one of the primary microorganisms for industrial L-lysine production due to its rapid growth, ease of genetic manipulation, and high production efficiency. This paper reviews the recent advances in E. coli strain engineering and fermentation process optimization for L-lysine production. Additionally, it discusses potential technological breakthroughs and challenges in E. coli-based L-lysine production, offering directions for future research to support industrial-scale production.
AB - lysine is an essential amino acid with significant importance, widely used in the food, feed, and pharmaceutical industries. To meet the increasing demand, microbial fermentation has emerged as an effective and sustainable method for L-lysine production. Escherichia coli has become one of the primary microorganisms for industrial L-lysine production due to its rapid growth, ease of genetic manipulation, and high production efficiency. This paper reviews the recent advances in E. coli strain engineering and fermentation process optimization for L-lysine production. Additionally, it discusses potential technological breakthroughs and challenges in E. coli-based L-lysine production, offering directions for future research to support industrial-scale production.
KW - Escherichia coli
KW - L-lysine
KW - fermentation optimization
KW - genome modification
KW - separation and purification
UR - http://www.scopus.com/inward/record.url?scp=85207030928&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2024.1485624
DO - 10.3389/fmicb.2024.1485624
M3 - 文献综述
AN - SCOPUS:85207030928
SN - 1664-302X
VL - 15
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 1485624
ER -