Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

Ran Ding; Zhi Dao Huang; Zheng Li Liu; Tian Xiang Wang; Yun He Xu; Teck Peng Loh

doi:10.1039/c5cc10653b

Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

Ran Ding, Zhi Dao Huang, Zheng Li Liu, Tian Xiang Wang, Yun He Xu, Teck Peng Loh

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.

Original language	English
Pages (from-to)	5617-5620
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	32
DOIs	https://doi.org/10.1039/c5cc10653b
State	Published - 25 Apr 2016
Externally published	Yes

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abstract = "Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.",

author = "Ran Ding and Huang, {Zhi Dao} and Liu, {Zheng Li} and Wang, {Tian Xiang} and Xu, {Yun He} and Loh, {Teck Peng}",

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T1 - Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

AU - Ding, Ran

AU - Huang, Zhi Dao

AU - Liu, Zheng Li

AU - Wang, Tian Xiang

AU - Xu, Yun He

AU - Loh, Teck Peng

PY - 2016/4/25

Y1 - 2016/4/25

N2 - Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.

AB - Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.

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U2 - 10.1039/c5cc10653b

DO - 10.1039/c5cc10653b

M3 - 文章

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JO - Chemical Communications

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ER -

Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

Abstract

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