Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

Ran Ding; Zhi Dao Huang; Zheng Li Liu; Tian Xiang Wang; Yun He Xu; Teck Peng Loh

doi:10.1039/c5cc10653b

Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

Ran Ding, Zhi Dao Huang, Zheng Li Liu, Tian Xiang Wang, Yun He Xu, Teck Peng Loh

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80 引用（Scopus）

摘要

Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.

源语言	英语
页（从-至）	5617-5620
页数	4
期刊	Chemical Communications
卷	52
期	32
DOI	https://doi.org/10.1039/c5cc10653b
出版状态	已出版 - 25 4月 2016
已对外发布	是

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abstract = "Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.",

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AU - Ding, Ran

AU - Huang, Zhi Dao

AU - Liu, Zheng Li

AU - Wang, Tian Xiang

AU - Xu, Yun He

AU - Loh, Teck Peng

PY - 2016/4/25

Y1 - 2016/4/25

N2 - Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.

AB - Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.

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Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

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