Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

Manikantha Maraswami; Sreekumar Pankajakshan; Gang Chen; Teck Peng Loh

doi:10.1021/acs.orglett.7b01859

Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

Manikantha Maraswami, Sreekumar Pankajakshan, Gang Chen, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

Original language	English
Pages (from-to)	4223-4226
Number of pages	4
Journal	Organic Letters
Volume	19
Issue number	16
DOIs	https://doi.org/10.1021/acs.orglett.7b01859
State	Published - 18 Aug 2017

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title = "Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides",

abstract = "A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.",

author = "Manikantha Maraswami and Sreekumar Pankajakshan and Gang Chen and Loh, {Teck Peng}",

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T1 - Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

AU - Maraswami, Manikantha

AU - Pankajakshan, Sreekumar

AU - Chen, Gang

AU - Loh, Teck Peng

PY - 2017/8/18

Y1 - 2017/8/18

N2 - A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

AB - A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

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JO - Organic Letters

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ER -

Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

Abstract

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