Pharmacokinetics of astragaloside iv in beagle dogs

Qi Zhang; Ling Ling Zhu; Guo Guang Chen; Yu Du

doi:10.1007/BF03190995

Pharmacokinetics of astragaloside iv in beagle dogs

Qi Zhang, Ling Ling Zhu, Guo Guang Chen, Yu Du

COLLEGE OF FOOD SCIENCE AND LIGHT INDUSTRY

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

In this study, the pharmacokinetics of Astragaloside iv (AGS-IV) in Beagle dogs was studied by high performance liquid chromatography (HPLC) coupled with tandem mass spectrometry (MS). The concentrations of the drugs in plasma were determined after i.v. administration of 0.5, 1, 2 mg·kg^-1 AGS-IV and p.o. administration of 10 mg·kg^-1 AGS-IV. The areas under concentration-time curve (AUC) were linearly correlated to the doses administrated. The absolute bioavailability of AGS-IV after p.o. administration was found to be 7.4%. The plasma protein binding rate of AGS-IV was about 90% within a concentration range of 250-1000 ng·ml^-1. There was no significant species difference regarding the pharmacokinetics of AGS-IV between the rat and the Beagle dog.

Original language	English
Pages (from-to)	75-79
Number of pages	5
Journal	European Journal of Drug Metabolism and Pharmacokinetics
Volume	32
Issue number	2
DOIs	https://doi.org/10.1007/BF03190995
State	Published - 2007

Keywords

Astragaloside iv (AGS-IV)
Beagle dogs
LC/MS/MS
Pharmacokinetics

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10.1007/BF03190995

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title = "Pharmacokinetics of astragaloside iv in beagle dogs",

abstract = "In this study, the pharmacokinetics of Astragaloside iv (AGS-IV) in Beagle dogs was studied by high performance liquid chromatography (HPLC) coupled with tandem mass spectrometry (MS). The concentrations of the drugs in plasma were determined after i.v. administration of 0.5, 1, 2 mg·kg-1 AGS-IV and p.o. administration of 10 mg·kg-1 AGS-IV. The areas under concentration-time curve (AUC) were linearly correlated to the doses administrated. The absolute bioavailability of AGS-IV after p.o. administration was found to be 7.4%. The plasma protein binding rate of AGS-IV was about 90% within a concentration range of 250-1000 ng·ml-1. There was no significant species difference regarding the pharmacokinetics of AGS-IV between the rat and the Beagle dog.",

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author = "Qi Zhang and Zhu, {Ling Ling} and Chen, {Guo Guang} and Yu Du",

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T1 - Pharmacokinetics of astragaloside iv in beagle dogs

AU - Zhang, Qi

AU - Zhu, Ling Ling

AU - Chen, Guo Guang

AU - Du, Yu

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AB - In this study, the pharmacokinetics of Astragaloside iv (AGS-IV) in Beagle dogs was studied by high performance liquid chromatography (HPLC) coupled with tandem mass spectrometry (MS). The concentrations of the drugs in plasma were determined after i.v. administration of 0.5, 1, 2 mg·kg-1 AGS-IV and p.o. administration of 10 mg·kg-1 AGS-IV. The areas under concentration-time curve (AUC) were linearly correlated to the doses administrated. The absolute bioavailability of AGS-IV after p.o. administration was found to be 7.4%. The plasma protein binding rate of AGS-IV was about 90% within a concentration range of 250-1000 ng·ml-1. There was no significant species difference regarding the pharmacokinetics of AGS-IV between the rat and the Beagle dog.

KW - Astragaloside iv (AGS-IV)

KW - Beagle dogs

KW - LC/MS/MS

KW - Pharmacokinetics

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JO - European Journal of Drug Metabolism and Pharmacokinetics

JF - European Journal of Drug Metabolism and Pharmacokinetics

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ER -

Pharmacokinetics of astragaloside iv in beagle dogs

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