Pharmacokinetics of astragaloside iv in beagle dogs

In this study, the pharmacokinetics of Astragaloside iv (AGS-IV) in Beagle dogs was studied by high performance liquid chromatography (HPLC) coupled with tandem mass spectrometry (MS). The concentrations of the drugs in plasma were determined after i.v. administration of 0.5, 1, 2 mg·kg^-1 AGS-IV and p.o. administration of 10 mg·kg^-1 AGS-IV. The areas under concentration-time curve (AUC) were linearly correlated to the doses administrated. The absolute bioavailability of AGS-IV after p.o. administration was found to be 7.4%. The plasma protein binding rate of AGS-IV was about 90% within a concentration range of 250-1000 ng·ml^-1. There was no significant species difference regarding the pharmacokinetics of AGS-IV between the rat and the Beagle dog.