Pharmacokinetics of astragaloside iv in beagle dogs

Qi Zhang, Ling Ling Zhu, Guo Guang Chen, Yu Du

科研成果: 期刊稿件文章同行评审

52 引用 (Scopus)

摘要

In this study, the pharmacokinetics of Astragaloside iv (AGS-IV) in Beagle dogs was studied by high performance liquid chromatography (HPLC) coupled with tandem mass spectrometry (MS). The concentrations of the drugs in plasma were determined after i.v. administration of 0.5, 1, 2 mg·kg-1 AGS-IV and p.o. administration of 10 mg·kg-1 AGS-IV. The areas under concentration-time curve (AUC) were linearly correlated to the doses administrated. The absolute bioavailability of AGS-IV after p.o. administration was found to be 7.4%. The plasma protein binding rate of AGS-IV was about 90% within a concentration range of 250-1000 ng·ml-1. There was no significant species difference regarding the pharmacokinetics of AGS-IV between the rat and the Beagle dog.

源语言英语
页(从-至)75-79
页数5
期刊European Journal of Drug Metabolism and Pharmacokinetics
32
2
DOI
出版状态已出版 - 2007

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