PH/glutathione-responsive release of SO2induced superoxide radical accumulation for gas therapy of cancer

Rui Gu; Lei Wang; Xiaoyu Huang; Jiayao Zhang; Changjin Ou; Weili Si; Jianguang Yu; Wenjun Wang; Xiaochen Dong

doi:10.1039/d0cc06826h

PH/glutathione-responsive release of SO₂induced superoxide radical accumulation for gas therapy of cancer

Rui Gu, Lei Wang, Xiaoyu Huang, Jiayao Zhang, Changjin Ou, Weili Si, Jianguang Yu, Wenjun Wang, Xiaochen Dong

SCHOOL OF FLEXIBLE ELECTRONICS(FUTURE TECHNOLOGIES)|INSTITUTE OF ADVANCED MATERIALS(IAM)

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A pH/GSH-responsive SO2 generation nanoplatform (BODS NPs) is established to achieve lysosomal escape and GSH depletion in tumor cells. O2- as the main ROS during SO2-mediated gas therapy can be accumulated through Cu/Zn-SOD enzymatic activity suppression and mitochondrial biogenesis, further exacerbating the oxidative stress and resulting in cell apoptosis.

Original language	English
Pages (from-to)	14865-14868
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	94
DOIs	https://doi.org/10.1039/d0cc06826h
State	Published - 7 Dec 2020

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10.1039/d0cc06826h

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title = "PH/glutathione-responsive release of SO2induced superoxide radical accumulation for gas therapy of cancer",

abstract = "A pH/GSH-responsive SO2 generation nanoplatform (BODS NPs) is established to achieve lysosomal escape and GSH depletion in tumor cells. O2- as the main ROS during SO2-mediated gas therapy can be accumulated through Cu/Zn-SOD enzymatic activity suppression and mitochondrial biogenesis, further exacerbating the oxidative stress and resulting in cell apoptosis.",

author = "Rui Gu and Lei Wang and Xiaoyu Huang and Jiayao Zhang and Changjin Ou and Weili Si and Jianguang Yu and Wenjun Wang and Xiaochen Dong",

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T1 - PH/glutathione-responsive release of SO2induced superoxide radical accumulation for gas therapy of cancer

AU - Gu, Rui

AU - Wang, Lei

AU - Huang, Xiaoyu

AU - Zhang, Jiayao

AU - Ou, Changjin

AU - Si, Weili

AU - Yu, Jianguang

AU - Wang, Wenjun

AU - Dong, Xiaochen

PY - 2020/12/7

Y1 - 2020/12/7

N2 - A pH/GSH-responsive SO2 generation nanoplatform (BODS NPs) is established to achieve lysosomal escape and GSH depletion in tumor cells. O2- as the main ROS during SO2-mediated gas therapy can be accumulated through Cu/Zn-SOD enzymatic activity suppression and mitochondrial biogenesis, further exacerbating the oxidative stress and resulting in cell apoptosis.

AB - A pH/GSH-responsive SO2 generation nanoplatform (BODS NPs) is established to achieve lysosomal escape and GSH depletion in tumor cells. O2- as the main ROS during SO2-mediated gas therapy can be accumulated through Cu/Zn-SOD enzymatic activity suppression and mitochondrial biogenesis, further exacerbating the oxidative stress and resulting in cell apoptosis.

UR - http://www.scopus.com/inward/record.url?scp=85096883475&partnerID=8YFLogxK

U2 - 10.1039/d0cc06826h

DO - 10.1039/d0cc06826h

M3 - 文章

C2 - 33174868

AN - SCOPUS:85096883475

SN - 1359-7345

VL - 56

SP - 14865

EP - 14868

JO - Chemical Communications

JF - Chemical Communications

IS - 94

ER -

PH/glutathione-responsive release of SO₂induced superoxide radical accumulation for gas therapy of cancer

Abstract

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