PH/glutathione-responsive release of SO2induced superoxide radical accumulation for gas therapy of cancer

Rui Gu, Lei Wang, Xiaoyu Huang, Jiayao Zhang, Changjin Ou, Weili Si, Jianguang Yu, Wenjun Wang, Xiaochen Dong

科研成果: 期刊稿件文章同行评审

35 引用 (Scopus)

摘要

A pH/GSH-responsive SO2 generation nanoplatform (BODS NPs) is established to achieve lysosomal escape and GSH depletion in tumor cells. O2- as the main ROS during SO2-mediated gas therapy can be accumulated through Cu/Zn-SOD enzymatic activity suppression and mitochondrial biogenesis, further exacerbating the oxidative stress and resulting in cell apoptosis.

源语言英语
页(从-至)14865-14868
页数4
期刊Chemical Communications
56
94
DOI
出版状态已出版 - 7 12月 2020

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