Phytic acid: A biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones

Qiguo Zhang; Xin Wang; Zhenjiang Li; Wenzhuo Wu; Jingjing Liu; Hao Wu; Saide Cui; Kai Guo

doi:10.1039/c4ra02084g

Phytic acid: A biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones

Qiguo Zhang, Xin Wang, Zhenjiang Li, Wenzhuo Wu, Jingjing Liu, Hao Wu, Saide Cui, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, solvent-free conditions, a simple workup, environmental friendliness, and a short reaction time.

Original language	English
Pages (from-to)	19710-19715
Number of pages	6
Journal	RSC Advances
Volume	4
Issue number	38
DOIs	https://doi.org/10.1039/c4ra02084g
State	Published - 2014

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title = "Phytic acid: A biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones",

abstract = "The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, solvent-free conditions, a simple workup, environmental friendliness, and a short reaction time.",

author = "Qiguo Zhang and Xin Wang and Zhenjiang Li and Wenzhuo Wu and Jingjing Liu and Hao Wu and Saide Cui and Kai Guo",

year = "2014",

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T2 - A biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones

AU - Zhang, Qiguo

AU - Wang, Xin

AU - Li, Zhenjiang

AU - Wu, Wenzhuo

AU - Liu, Jingjing

AU - Wu, Hao

AU - Cui, Saide

AU - Guo, Kai

PY - 2014

Y1 - 2014

N2 - The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, solvent-free conditions, a simple workup, environmental friendliness, and a short reaction time.

AB - The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, solvent-free conditions, a simple workup, environmental friendliness, and a short reaction time.

UR - http://www.scopus.com/inward/record.url?scp=84899796326&partnerID=8YFLogxK

U2 - 10.1039/c4ra02084g

DO - 10.1039/c4ra02084g

M3 - 文章

AN - SCOPUS:84899796326

SN - 2046-2069

VL - 4

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JO - RSC Advances

JF - RSC Advances

IS - 38

ER -

Phytic acid: A biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones

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