Phytic acid: A biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones

Qiguo Zhang; Xin Wang; Zhenjiang Li; Wenzhuo Wu; Jingjing Liu; Hao Wu; Saide Cui; Kai Guo

doi:10.1039/c4ra02084g

Phytic acid: A biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones

Qiguo Zhang, Xin Wang, Zhenjiang Li, Wenzhuo Wu, Jingjing Liu, Hao Wu, Saide Cui, Kai Guo

生物与制药工程学院

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

48 引用（Scopus）

摘要

The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, solvent-free conditions, a simple workup, environmental friendliness, and a short reaction time.

源语言	英语
页（从-至）	19710-19715
页数	6
期刊	RSC Advances
卷	4
期	38
DOI	https://doi.org/10.1039/c4ra02084g
出版状态	已出版 - 2014

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abstract = "The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, solvent-free conditions, a simple workup, environmental friendliness, and a short reaction time.",

author = "Qiguo Zhang and Xin Wang and Zhenjiang Li and Wenzhuo Wu and Jingjing Liu and Hao Wu and Saide Cui and Kai Guo",

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AU - Zhang, Qiguo

AU - Wang, Xin

AU - Li, Zhenjiang

AU - Wu, Wenzhuo

AU - Liu, Jingjing

AU - Wu, Hao

AU - Cui, Saide

AU - Guo, Kai

PY - 2014

Y1 - 2014

N2 - The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, solvent-free conditions, a simple workup, environmental friendliness, and a short reaction time.

AB - The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, solvent-free conditions, a simple workup, environmental friendliness, and a short reaction time.

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Phytic acid: A biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones

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