Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction

Dong Zhang; Yu Sun; Ganwen Wang; Ying Liu; Chunjie Ni; Qingzhi Ji; Xiaojuan Xu; Zheng Fang

doi:10.1021/acs.joc.4c01528

Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction

Dong Zhang, Yu Sun, Ganwen Wang, Ying Liu, Chunjie Ni, Qingzhi Ji, Xiaojuan Xu, Zheng Fang

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Yancheng Teachers University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF₂SO₂Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.

Original language	English
Pages (from-to)	13367-13372
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	89
Issue number	18
DOIs	https://doi.org/10.1021/acs.joc.4c01528
State	Published - 20 Sep 2024

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title = "Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction",

abstract = "An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF2SO2Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.",

author = "Dong Zhang and Yu Sun and Ganwen Wang and Ying Liu and Chunjie Ni and Qingzhi Ji and Xiaojuan Xu and Zheng Fang",

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T1 - Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction

AU - Zhang, Dong

AU - Sun, Yu

AU - Wang, Ganwen

AU - Liu, Ying

AU - Ni, Chunjie

AU - Ji, Qingzhi

AU - Xu, Xiaojuan

AU - Fang, Zheng

PY - 2024/9/20

Y1 - 2024/9/20

N2 - An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF2SO2Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.

AB - An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF2SO2Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.

UR - http://www.scopus.com/inward/record.url?scp=85203280820&partnerID=8YFLogxK

U2 - 10.1021/acs.joc.4c01528

DO - 10.1021/acs.joc.4c01528

M3 - 文章

AN - SCOPUS:85203280820

SN - 0022-3263

VL - 89

SP - 13367

EP - 13372

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 18

ER -

Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction

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