Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction

Dong Zhang; Yu Sun; Ganwen Wang; Ying Liu; Chunjie Ni; Qingzhi Ji; Xiaojuan Xu; Zheng Fang

doi:10.1021/acs.joc.4c01528

Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction

Dong Zhang, Yu Sun, Ganwen Wang, Ying Liu, Chunjie Ni, Qingzhi Ji, Xiaojuan Xu, Zheng Fang

生物与制药工程学院

Yancheng Teachers University

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF₂SO₂Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.

源语言	英语
页（从-至）	13367-13372
页数	6
期刊	Journal of Organic Chemistry
卷	89
期	18
DOI	https://doi.org/10.1021/acs.joc.4c01528
出版状态	已出版 - 20 9月 2024

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10.1021/acs.joc.4c01528

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title = "Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction",

abstract = "An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF2SO2Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.",

author = "Dong Zhang and Yu Sun and Ganwen Wang and Ying Liu and Chunjie Ni and Qingzhi Ji and Xiaojuan Xu and Zheng Fang",

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year = "2024",

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doi = "10.1021/acs.joc.4c01528",

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TY - JOUR

T1 - Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction

AU - Zhang, Dong

AU - Sun, Yu

AU - Wang, Ganwen

AU - Liu, Ying

AU - Ni, Chunjie

AU - Ji, Qingzhi

AU - Xu, Xiaojuan

AU - Fang, Zheng

PY - 2024/9/20

Y1 - 2024/9/20

N2 - An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF2SO2Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.

AB - An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF2SO2Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.

UR - http://www.scopus.com/inward/record.url?scp=85203280820&partnerID=8YFLogxK

U2 - 10.1021/acs.joc.4c01528

DO - 10.1021/acs.joc.4c01528

M3 - 文章

AN - SCOPUS:85203280820

SN - 0022-3263

VL - 89

SP - 13367

EP - 13372

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 18

ER -

Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction

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