Abstract
In the past two decades, water has gradually become a green and sustainable alternative to traditional organic solvents which are generally hazardous and waste productive. Due to its safe, nontoxic, nonflammable, cost-effective, and abundant nature, water has been increasingly used in various types of organic reactions ranging from conventional oxidation, reduction, addition, substitution, condensation, cyclization reactions to classical cross-coupling, C-H activation reactions and more recent photoredox, electrochemical and chemoenzymatic reactions. This chapter summarizes recent (2017-2022) representative examples of various types of reactions using water as the solvent and covers related reaction mechanisms and the roles that water plays in certain reactions. Micellar-enabled aqueous reactions facilitated by various types of surfactants will also be discussed.
| Original language | English |
|---|---|
| Title of host publication | Green Solvents in Organic Synthesis |
| Publisher | wiley |
| Pages | 317-442 |
| Number of pages | 126 |
| ISBN (Electronic) | 9783527841943 |
| ISBN (Print) | 9783527352005 |
| DOIs | |
| State | Published - 8 Mar 2024 |
Keywords
- Aqueous
- C-H functionalization
- Chemoenzymatic
- Cross-coupling
- Electrochemical
- In water
- Micellar
- On water
- Photoredox
- Transition metals