Regio-and stereoselective C(sp2)-H acylation of enamides with aldehydes: Via transition-metal-free photoredox catalysis

Kai Zhao; Xiao Chen Zhang; Ji Yu Tao; Xian Dan Wu; Jia Xu Wu; Wei Ming Li; Tong Hao Zhu; Teck Peng Loh

doi:10.1039/d0gc01947j

Regio-and stereoselective C(sp²)-H acylation of enamides with aldehydes: Via transition-metal-free photoredox catalysis

Kai Zhao, Xiao Chen Zhang, Ji Yu Tao, Xian Dan Wu, Jia Xu Wu, Wei Ming Li, Tong Hao Zhu, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

A straightforward and efficient C(sp2)-H acylation of enamides with aldehydes via transition-metal-free photoredox catalysis is demonstrated. The transformation proceeded smoothly without resorting to expensive and potentially toxic iridium or ruthenium polypyridyl-based photocatalysts under mild conditions, furnishing a diverse range of synthetically crucial, geometrically defined β-acylated enamides in a stereoselective and regioselective manner.

Original language	English
Pages (from-to)	5497-5503
Number of pages	7
Journal	Green Chemistry
Volume	22
Issue number	16
DOIs	https://doi.org/10.1039/d0gc01947j
State	Published - 21 Aug 2020

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title = "Regio-and stereoselective C(sp2)-H acylation of enamides with aldehydes: Via transition-metal-free photoredox catalysis",

abstract = "A straightforward and efficient C(sp2)-H acylation of enamides with aldehydes via transition-metal-free photoredox catalysis is demonstrated. The transformation proceeded smoothly without resorting to expensive and potentially toxic iridium or ruthenium polypyridyl-based photocatalysts under mild conditions, furnishing a diverse range of synthetically crucial, geometrically defined β-acylated enamides in a stereoselective and regioselective manner.",

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T2 - Via transition-metal-free photoredox catalysis

AU - Zhao, Kai

AU - Zhang, Xiao Chen

AU - Tao, Ji Yu

AU - Wu, Xian Dan

AU - Wu, Jia Xu

AU - Li, Wei Ming

AU - Zhu, Tong Hao

AU - Loh, Teck Peng

PY - 2020/8/21

Y1 - 2020/8/21

N2 - A straightforward and efficient C(sp2)-H acylation of enamides with aldehydes via transition-metal-free photoredox catalysis is demonstrated. The transformation proceeded smoothly without resorting to expensive and potentially toxic iridium or ruthenium polypyridyl-based photocatalysts under mild conditions, furnishing a diverse range of synthetically crucial, geometrically defined β-acylated enamides in a stereoselective and regioselective manner.

AB - A straightforward and efficient C(sp2)-H acylation of enamides with aldehydes via transition-metal-free photoredox catalysis is demonstrated. The transformation proceeded smoothly without resorting to expensive and potentially toxic iridium or ruthenium polypyridyl-based photocatalysts under mild conditions, furnishing a diverse range of synthetically crucial, geometrically defined β-acylated enamides in a stereoselective and regioselective manner.

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DO - 10.1039/d0gc01947j

M3 - 文章

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JO - Green Chemistry

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ER -

Regio-and stereoselective C(sp²)-H acylation of enamides with aldehydes: Via transition-metal-free photoredox catalysis

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