Regioselective and Stereoselective Difluoromethylation of Enamides with Difluoromethyltriphenylphosphonium Bromide via Photoredox Catalysis

Tong Hao Zhu; Ze Yu Zhang; Ji Yu Tao; Kai Zhao; Teck Peng Loh

doi:10.1021/acs.orglett.9b02361

Regioselective and Stereoselective Difluoromethylation of Enamides with Difluoromethyltriphenylphosphonium Bromide via Photoredox Catalysis

Tong Hao Zhu, Ze Yu Zhang, Ji Yu Tao, Kai Zhao, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

A regioselective and stereoselective difluoromethylation of enamides with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide is described. A broad array of synthetically important and geometrically defined β-difluoromethylated enamides bearing various functional groups are obtained with up to 91% yield.

Original language	English
Pages (from-to)	6155-6159
Number of pages	5
Journal	Organic Letters
Volume	21
Issue number	15
DOIs	https://doi.org/10.1021/acs.orglett.9b02361
State	Published - 2 Aug 2019

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title = "Regioselective and Stereoselective Difluoromethylation of Enamides with Difluoromethyltriphenylphosphonium Bromide via Photoredox Catalysis",

abstract = "A regioselective and stereoselective difluoromethylation of enamides with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide is described. A broad array of synthetically important and geometrically defined β-difluoromethylated enamides bearing various functional groups are obtained with up to 91% yield.",

author = "Zhu, {Tong Hao} and Zhang, {Ze Yu} and Tao, {Ji Yu} and Kai Zhao and Loh, {Teck Peng}",

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AU - Zhu, Tong Hao

AU - Zhang, Ze Yu

AU - Tao, Ji Yu

AU - Zhao, Kai

AU - Loh, Teck Peng

PY - 2019/8/2

Y1 - 2019/8/2

N2 - A regioselective and stereoselective difluoromethylation of enamides with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide is described. A broad array of synthetically important and geometrically defined β-difluoromethylated enamides bearing various functional groups are obtained with up to 91% yield.

AB - A regioselective and stereoselective difluoromethylation of enamides with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide is described. A broad array of synthetically important and geometrically defined β-difluoromethylated enamides bearing various functional groups are obtained with up to 91% yield.

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M3 - 文章

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AN - SCOPUS:85070540568

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ER -

Regioselective and Stereoselective Difluoromethylation of Enamides with Difluoromethyltriphenylphosphonium Bromide via Photoredox Catalysis

Abstract

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