Research progress of echinocandins pneumocandin production by Glarea lozoyensis

Ping Song; Ren Chuan Zhang; Kun Da Feng; Xiao Jun Ji; He Huang

Research progress of echinocandins pneumocandin production by Glarea lozoyensis

Ping Song, Ren Chuan Zhang, Kun Da Feng, Xiao Jun Ji, He Huang

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Pneumocandin B₀ is a precusor of antifungal echinocandins caspofungin. The echinocandins are a class of antifungal lipopeptides targeting fungi via noncompetitive inhibition of the β-1,3-D-glucan synthase enzyme complex, leading to glucan polymer depletion in the fungal cell wall and resulting in osmotic instability and fungal cell lysis. Pneumocandin B₀ is produced by fungi Glarea lozoyensis. This article reviews the recent advance on pneumocandin B₀, including the structure, biosynthesis, strain breeding and fermentation production.

Original language	English
Pages (from-to)	6-12
Number of pages	7
Journal	Chinese Journal of Antibiotics
Volume	40
Issue number	1
State	Published - 2015

Keywords

Antifungal drugs
Caspofungin
Lipopeptide
Pneumocandin

Cite this

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title = "Research progress of echinocandins pneumocandin production by Glarea lozoyensis",

abstract = "Pneumocandin B0 is a precusor of antifungal echinocandins caspofungin. The echinocandins are a class of antifungal lipopeptides targeting fungi via noncompetitive inhibition of the β-1,3-D-glucan synthase enzyme complex, leading to glucan polymer depletion in the fungal cell wall and resulting in osmotic instability and fungal cell lysis. Pneumocandin B0 is produced by fungi Glarea lozoyensis. This article reviews the recent advance on pneumocandin B0, including the structure, biosynthesis, strain breeding and fermentation production.",

keywords = "Antifungal drugs, Caspofungin, Lipopeptide, Pneumocandin",

author = "Ping Song and Zhang, {Ren Chuan} and Feng, {Kun Da} and Ji, {Xiao Jun} and He Huang",

year = "2015",

language = "英语",

volume = "40",

pages = "6--12",

journal = "Chinese Journal of Antibiotics",

issn = "1001-8689",

publisher = "Editorial Office of Chinese Journal of Antibiotics",

number = "1",

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TY - JOUR

T1 - Research progress of echinocandins pneumocandin production by Glarea lozoyensis

AU - Song, Ping

AU - Zhang, Ren Chuan

AU - Feng, Kun Da

AU - Ji, Xiao Jun

AU - Huang, He

PY - 2015

Y1 - 2015

N2 - Pneumocandin B0 is a precusor of antifungal echinocandins caspofungin. The echinocandins are a class of antifungal lipopeptides targeting fungi via noncompetitive inhibition of the β-1,3-D-glucan synthase enzyme complex, leading to glucan polymer depletion in the fungal cell wall and resulting in osmotic instability and fungal cell lysis. Pneumocandin B0 is produced by fungi Glarea lozoyensis. This article reviews the recent advance on pneumocandin B0, including the structure, biosynthesis, strain breeding and fermentation production.

AB - Pneumocandin B0 is a precusor of antifungal echinocandins caspofungin. The echinocandins are a class of antifungal lipopeptides targeting fungi via noncompetitive inhibition of the β-1,3-D-glucan synthase enzyme complex, leading to glucan polymer depletion in the fungal cell wall and resulting in osmotic instability and fungal cell lysis. Pneumocandin B0 is produced by fungi Glarea lozoyensis. This article reviews the recent advance on pneumocandin B0, including the structure, biosynthesis, strain breeding and fermentation production.

KW - Antifungal drugs

KW - Caspofungin

KW - Lipopeptide

KW - Pneumocandin

UR - http://www.scopus.com/inward/record.url?scp=84942616786&partnerID=8YFLogxK

M3 - 文章

AN - SCOPUS:84942616786

SN - 1001-8689

VL - 40

SP - 6

EP - 12

JO - Chinese Journal of Antibiotics

JF - Chinese Journal of Antibiotics

IS - 1

ER -

Research progress of echinocandins pneumocandin production by Glarea lozoyensis

Abstract

Keywords

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