Synthesis of Mono-fluoroallenes through Copper-Catalyzed Defluorinative Silylation of α,α-Difluoroalkylalkynes

Luning Tang; Bing Bing Pei; Yang Song; Fei Xue; Yanni Yue; Chao Feng

doi:10.1002/cjoc.202200138

Synthesis of Mono-fluoroallenes through Copper-Catalyzed Defluorinative Silylation of α,α-Difluoroalkylalkynes

Luning Tang, Bing Bing Pei, Yang Song, Fei Xue, Yanni Yue, Chao Feng

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A straightforward protocol for the synthesis of mono-fluorinated allenes via catalytic defluorinative silylation of the readily available α,α-difluoroalkylalkynes with commercially available copper catalyst and phosphine ligand is described. A broad scope of α,α-difluoroalkylalkynes were well accommodated and a gram-scale synthesis demonstrated the synthetic utility of this methodoglogy.

Original language	English
Pages (from-to)	2035-2039
Number of pages	5
Journal	Chinese Journal of Chemistry
Volume	40
Issue number	17
DOIs	https://doi.org/10.1002/cjoc.202200138
State	Published - 1 Sep 2022

Keywords

Allenes
Copper
Defluorination
Silylation
α,α-Difluoroalkylalkyne

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10.1002/cjoc.202200138

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title = "Synthesis of Mono-fluoroallenes through Copper-Catalyzed Defluorinative Silylation of α,α-Difluoroalkylalkynes",

abstract = "A straightforward protocol for the synthesis of mono-fluorinated allenes via catalytic defluorinative silylation of the readily available α,α-difluoroalkylalkynes with commercially available copper catalyst and phosphine ligand is described. A broad scope of α,α-difluoroalkylalkynes were well accommodated and a gram-scale synthesis demonstrated the synthetic utility of this methodoglogy.",

keywords = "Allenes, Copper, Defluorination, Silylation, α,α-Difluoroalkylalkyne",

author = "Luning Tang and Pei, {Bing Bing} and Yang Song and Fei Xue and Yanni Yue and Chao Feng",

note = "Publisher Copyright: {\textcopyright} 2022 SIOC, CAS, Shanghai, & WILEY-VCH GmbH.",

year = "2022",

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doi = "10.1002/cjoc.202200138",

language = "英语",

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TY - JOUR

T1 - Synthesis of Mono-fluoroallenes through Copper-Catalyzed Defluorinative Silylation of α,α-Difluoroalkylalkynes

AU - Tang, Luning

AU - Pei, Bing Bing

AU - Song, Yang

AU - Xue, Fei

AU - Yue, Yanni

AU - Feng, Chao

PY - 2022/9/1

Y1 - 2022/9/1

N2 - A straightforward protocol for the synthesis of mono-fluorinated allenes via catalytic defluorinative silylation of the readily available α,α-difluoroalkylalkynes with commercially available copper catalyst and phosphine ligand is described. A broad scope of α,α-difluoroalkylalkynes were well accommodated and a gram-scale synthesis demonstrated the synthetic utility of this methodoglogy.

AB - A straightforward protocol for the synthesis of mono-fluorinated allenes via catalytic defluorinative silylation of the readily available α,α-difluoroalkylalkynes with commercially available copper catalyst and phosphine ligand is described. A broad scope of α,α-difluoroalkylalkynes were well accommodated and a gram-scale synthesis demonstrated the synthetic utility of this methodoglogy.

KW - Allenes

KW - Copper

KW - Defluorination

KW - Silylation

KW - α,α-Difluoroalkylalkyne

UR - http://www.scopus.com/inward/record.url?scp=85132561642&partnerID=8YFLogxK

U2 - 10.1002/cjoc.202200138

DO - 10.1002/cjoc.202200138

M3 - 文章

AN - SCOPUS:85132561642

SN - 1001-604X

VL - 40

SP - 2035

EP - 2039

JO - Chinese Journal of Chemistry

JF - Chinese Journal of Chemistry

IS - 17

ER -

Synthesis of Mono-fluoroallenes through Copper-Catalyzed Defluorinative Silylation of α,α-Difluoroalkylalkynes

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Keywords

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