Synthesis of pyrido[1,2-a]indol-6(7H)-ones via a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes

Minghui Wei; Chengkou Liu; Chang Sheng Wang; Yuguang Li; Peng Qiu; Quanxiao Dong; Zhao Yang; Zheng Fang; Kai Guo

doi:10.1039/d2gc04491a

Synthesis of pyrido[1,2-a]indol-6(7H)-ones via a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes

Minghui Wei, Chengkou Liu, Chang Sheng Wang, Yuguang Li, Peng Qiu, Quanxiao Dong, Zhao Yang, Zheng Fang, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We successfully developed an unprecedented synthesis route to pyrido[1,2-a]indol-6(7H)-ones through a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes in a microchannel reactor. This novel protocol features extremely mild conditions, a broad substrate scope and high reaction efficiency. In addition, a reasonable reaction mechanism based on controlled experiments was proposed.

Original language	English
Pages (from-to)	2453-2457
Number of pages	5
Journal	Green Chemistry
Volume	25
Issue number	6
DOIs	https://doi.org/10.1039/d2gc04491a
State	Published - 10 Mar 2023

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title = "Synthesis of pyrido[1,2-a]indol-6(7H)-ones via a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes",

abstract = "We successfully developed an unprecedented synthesis route to pyrido[1,2-a]indol-6(7H)-ones through a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes in a microchannel reactor. This novel protocol features extremely mild conditions, a broad substrate scope and high reaction efficiency. In addition, a reasonable reaction mechanism based on controlled experiments was proposed.",

author = "Minghui Wei and Chengkou Liu and Wang, {Chang Sheng} and Yuguang Li and Peng Qiu and Quanxiao Dong and Zhao Yang and Zheng Fang and Kai Guo",

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T1 - Synthesis of pyrido[1,2-a]indol-6(7H)-ones via a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes

AU - Wei, Minghui

AU - Liu, Chengkou

AU - Wang, Chang Sheng

AU - Li, Yuguang

AU - Qiu, Peng

AU - Dong, Quanxiao

AU - Yang, Zhao

AU - Fang, Zheng

AU - Guo, Kai

PY - 2023/3/10

Y1 - 2023/3/10

N2 - We successfully developed an unprecedented synthesis route to pyrido[1,2-a]indol-6(7H)-ones through a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes in a microchannel reactor. This novel protocol features extremely mild conditions, a broad substrate scope and high reaction efficiency. In addition, a reasonable reaction mechanism based on controlled experiments was proposed.

AB - We successfully developed an unprecedented synthesis route to pyrido[1,2-a]indol-6(7H)-ones through a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes in a microchannel reactor. This novel protocol features extremely mild conditions, a broad substrate scope and high reaction efficiency. In addition, a reasonable reaction mechanism based on controlled experiments was proposed.

UR - http://www.scopus.com/inward/record.url?scp=85150435485&partnerID=8YFLogxK

U2 - 10.1039/d2gc04491a

DO - 10.1039/d2gc04491a

M3 - 文章

AN - SCOPUS:85150435485

SN - 1463-9262

VL - 25

SP - 2453

EP - 2457

JO - Green Chemistry

JF - Green Chemistry

IS - 6

ER -

Synthesis of pyrido[1,2-a]indol-6(7H)-ones via a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes

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