Abstract
The acid free asymmetric intermolecular α-alkylation of aldehydes with alcohols has been discovered using trifluoroethanol as solvent. This unprecedented system affords the enantioenriched functionalized primary alcohols (after NaBH4 reduction) in high yields and good to excellent enantioselectivities with wide substrate scope in the absence of any acid additive.
| Original language | English |
|---|---|
| Pages (from-to) | 3548-3550 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 48 |
| Issue number | 29 |
| DOIs | |
| State | Published - 12 Mar 2012 |
| Externally published | Yes |