摘要
The acid free asymmetric intermolecular α-alkylation of aldehydes with alcohols has been discovered using trifluoroethanol as solvent. This unprecedented system affords the enantioenriched functionalized primary alcohols (after NaBH4 reduction) in high yields and good to excellent enantioselectivities with wide substrate scope in the absence of any acid additive.
| 源语言 | 英语 |
|---|---|
| 页（从-至） | 3548-3550 |
| 页数 | 3 |
| 期刊 | Chemical Communications |
| 卷 | 48 |
| 期 | 29 |
| DOI | |
| 出版状态 | 已出版 - 12 3月 2012 |
| 已对外发布 | 是 |