Total synthesis of phytophthora mating hormone α1

Shun Yi Wang; Ping Song; Li Yan Chan; Teck Peng Loh

doi:10.1021/ol102177j

Total synthesis of phytophthora mating hormone α1

Shun Yi Wang, Ping Song, Li Yan Chan, Teck Peng Loh

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Total synthesis of Phytophthora mating hormone α1 (1) has been demonstrated. The required stereochemistries (methyl) are achieved by applying CuI-(S)-Tol-BINAP-catalyzed conjugate addition of Grignard reagents to α,β-unsaturated esters.

Original language	English
Pages (from-to)	5166-5169
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	22
DOIs	https://doi.org/10.1021/ol102177j
State	Published - 19 Nov 2010
Externally published	Yes

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title = "Total synthesis of phytophthora mating hormone α1",

abstract = "Total synthesis of Phytophthora mating hormone α1 (1) has been demonstrated. The required stereochemistries (methyl) are achieved by applying CuI-(S)-Tol-BINAP-catalyzed conjugate addition of Grignard reagents to α,β-unsaturated esters.",

author = "Wang, {Shun Yi} and Ping Song and Chan, {Li Yan} and Loh, {Teck Peng}",

year = "2010",

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doi = "10.1021/ol102177j",

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journal = "Organic Letters",

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AU - Wang, Shun Yi

AU - Song, Ping

AU - Chan, Li Yan

AU - Loh, Teck Peng

PY - 2010/11/19

Y1 - 2010/11/19

N2 - Total synthesis of Phytophthora mating hormone α1 (1) has been demonstrated. The required stereochemistries (methyl) are achieved by applying CuI-(S)-Tol-BINAP-catalyzed conjugate addition of Grignard reagents to α,β-unsaturated esters.

AB - Total synthesis of Phytophthora mating hormone α1 (1) has been demonstrated. The required stereochemistries (methyl) are achieved by applying CuI-(S)-Tol-BINAP-catalyzed conjugate addition of Grignard reagents to α,β-unsaturated esters.

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U2 - 10.1021/ol102177j

DO - 10.1021/ol102177j

M3 - 文章

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SN - 1523-7060

VL - 12

SP - 5166

EP - 5169

JO - Organic Letters

JF - Organic Letters

IS - 22

ER -

Total synthesis of phytophthora mating hormone α1

Abstract

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