Transalkylation via C-N Bond Cleavage of Amines Catalyzed by Super Organophotoreductant CBZ6

Yong Ze Chen, Yi Ming Chen, Yuan Hu, Jian Ping Qu, Yan Biao Kang

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The super organoreductant CBZ6-catalyzed tandem transalkylation-cyclization using amines as traceless radical donors and stabilizer is reported. The later-stage breaking of an N-C bond enables the transalkylation with a secondary amine as the leaving moiety. A wide range of tertiary amines were used as alkyl radical donors for the C1-C8 alkyls. This traceless stabilizer also enabled the transalkylation with methyl radical, which is normally not possible because of the instability of methyl radical.

Original languageEnglish
Pages (from-to)7518-7522
Number of pages5
JournalOrganic Letters
Volume25
Issue number41
DOIs
StatePublished - 20 Oct 2023

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