Abstract
The super organoreductant CBZ6-catalyzed tandem transalkylation-cyclization using amines as traceless radical donors and stabilizer is reported. The later-stage breaking of an N-C bond enables the transalkylation with a secondary amine as the leaving moiety. A wide range of tertiary amines were used as alkyl radical donors for the C1-C8 alkyls. This traceless stabilizer also enabled the transalkylation with methyl radical, which is normally not possible because of the instability of methyl radical.
Original language | English |
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Pages (from-to) | 7518-7522 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 25 |
Issue number | 41 |
DOIs | |
State | Published - 20 Oct 2023 |