A blood compatible, high-efficient sensor for detection of Cr(VI) in whole blood

Dan Fang; Tingting Xu; Leyi Fang; Huan Chen; Yangyang Huang; Huanyu Zhang; Zhuoyue Miao; Chun Mao; Bo Chi; Hong Xu

doi:10.1016/j.snb.2020.129219

A blood compatible, high-efficient sensor for detection of Cr(VI) in whole blood

Dan Fang, Tingting Xu, Leyi Fang, Huan Chen, Yangyang Huang, Huanyu Zhang, Zhuoyue Miao, Chun Mao, Bo Chi, Hong Xu

食品与轻工学院

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15 引用（Scopus）

摘要

Fast and accurate test Cr(VI) in the whole blood is particularly critical for the treatment and prevention of Cr(VI) poisoning. Here, a blood compatible, high-efficient sensor based on the magnetic glassy carbon electrode (MGCE) that modified by conductive polyaniline (PANI), heparin and tannin modified Fe₃O₄ nanoparticles (magnetic tannin-modified adsorbent, MTA) with high adsorption ability toward Cr(VI) ions was developed. Results indicated the designed PANI/Hep/MTA/MGCE exhibited high sensitivity for Cr(VI) in the concentration range of 10⁻⁷ to 10⁻⁴ ppm with a 0.87 μM detection limit (3σ method). In particular, this prepared sensor not only exhibited outstanding electrochemical performance for Cr(VI) detection, but also possessed good antibiofouling characteristics due to the existence of heparin, which can provide guarantee for direct detection of Cr(VI) in the whole blood.

源语言	英语
文章编号	129219
期刊	Sensors and Actuators B: Chemical
卷	329
DOI	https://doi.org/10.1016/j.snb.2020.129219
出版状态	已出版 - 15 2月 2021

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title = "A blood compatible, high-efficient sensor for detection of Cr(VI) in whole blood",

abstract = "Fast and accurate test Cr(VI) in the whole blood is particularly critical for the treatment and prevention of Cr(VI) poisoning. Here, a blood compatible, high-efficient sensor based on the magnetic glassy carbon electrode (MGCE) that modified by conductive polyaniline (PANI), heparin and tannin modified Fe3O4 nanoparticles (magnetic tannin-modified adsorbent, MTA) with high adsorption ability toward Cr(VI) ions was developed. Results indicated the designed PANI/Hep/MTA/MGCE exhibited high sensitivity for Cr(VI) in the concentration range of 10−7 to 10−4 ppm with a 0.87 μM detection limit (3σ method). In particular, this prepared sensor not only exhibited outstanding electrochemical performance for Cr(VI) detection, but also possessed good antibiofouling characteristics due to the existence of heparin, which can provide guarantee for direct detection of Cr(VI) in the whole blood.",

keywords = "Antibiofouling, Cr(VI) sensor, Electrode surface modification, Whole blood",

author = "Dan Fang and Tingting Xu and Leyi Fang and Huan Chen and Yangyang Huang and Huanyu Zhang and Zhuoyue Miao and Chun Mao and Bo Chi and Hong Xu",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2021",

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day = "15",

doi = "10.1016/j.snb.2020.129219",

language = "英语",

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journal = "Sensors and Actuators B: Chemical",

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TY - JOUR

T1 - A blood compatible, high-efficient sensor for detection of Cr(VI) in whole blood

AU - Fang, Dan

AU - Xu, Tingting

AU - Fang, Leyi

AU - Chen, Huan

AU - Huang, Yangyang

AU - Zhang, Huanyu

AU - Miao, Zhuoyue

AU - Mao, Chun

AU - Chi, Bo

AU - Xu, Hong

PY - 2021/2/15

Y1 - 2021/2/15

N2 - Fast and accurate test Cr(VI) in the whole blood is particularly critical for the treatment and prevention of Cr(VI) poisoning. Here, a blood compatible, high-efficient sensor based on the magnetic glassy carbon electrode (MGCE) that modified by conductive polyaniline (PANI), heparin and tannin modified Fe3O4 nanoparticles (magnetic tannin-modified adsorbent, MTA) with high adsorption ability toward Cr(VI) ions was developed. Results indicated the designed PANI/Hep/MTA/MGCE exhibited high sensitivity for Cr(VI) in the concentration range of 10−7 to 10−4 ppm with a 0.87 μM detection limit (3σ method). In particular, this prepared sensor not only exhibited outstanding electrochemical performance for Cr(VI) detection, but also possessed good antibiofouling characteristics due to the existence of heparin, which can provide guarantee for direct detection of Cr(VI) in the whole blood.

AB - Fast and accurate test Cr(VI) in the whole blood is particularly critical for the treatment and prevention of Cr(VI) poisoning. Here, a blood compatible, high-efficient sensor based on the magnetic glassy carbon electrode (MGCE) that modified by conductive polyaniline (PANI), heparin and tannin modified Fe3O4 nanoparticles (magnetic tannin-modified adsorbent, MTA) with high adsorption ability toward Cr(VI) ions was developed. Results indicated the designed PANI/Hep/MTA/MGCE exhibited high sensitivity for Cr(VI) in the concentration range of 10−7 to 10−4 ppm with a 0.87 μM detection limit (3σ method). In particular, this prepared sensor not only exhibited outstanding electrochemical performance for Cr(VI) detection, but also possessed good antibiofouling characteristics due to the existence of heparin, which can provide guarantee for direct detection of Cr(VI) in the whole blood.

KW - Antibiofouling

KW - Cr(VI) sensor

KW - Electrode surface modification

KW - Whole blood

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U2 - 10.1016/j.snb.2020.129219

DO - 10.1016/j.snb.2020.129219

M3 - 文章

AN - SCOPUS:85097095846

SN - 0925-4005

VL - 329

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

M1 - 129219

ER -

A blood compatible, high-efficient sensor for detection of Cr(VI) in whole blood

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