A sensitive and selective fluorescence probe based fluorescein for detection of hypochlorous acid and its application for biological imaging

Wenzhu Yin; Hongjun Zhu; Ruiyong Wang

doi:10.1016/j.dyepig.2014.03.012

A sensitive and selective fluorescence probe based fluorescein for detection of hypochlorous acid and its application for biological imaging

Wenzhu Yin, Hongjun Zhu, Ruiyong Wang

化学与分子工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

92 引用（Scopus）

摘要

A highly sensitive and selective fluorescein-based probe 1 for hypochlorite anion was synthesized. The probe 1 has favorable characteristics for biological imaging, including high water solubility, high fluorescence yield, pH-independent fluorescence, and biocompatibility. Results show that it has a detection limit of 40 nM to hypochlorite anion. In addition, confocal fluorescence microscopy imaging using RAW264.7 cells showed that the new probe 1 could be used as an effective fluorescent probe for detecting HOCl in living cells.

源语言	英语
页（从-至）	127-132
页数	6
期刊	Dyes and Pigments
卷	107
DOI	https://doi.org/10.1016/j.dyepig.2014.03.012
出版状态	已出版 - 8月 2014

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abstract = "A highly sensitive and selective fluorescein-based probe 1 for hypochlorite anion was synthesized. The probe 1 has favorable characteristics for biological imaging, including high water solubility, high fluorescence yield, pH-independent fluorescence, and biocompatibility. Results show that it has a detection limit of 40 nM to hypochlorite anion. In addition, confocal fluorescence microscopy imaging using RAW264.7 cells showed that the new probe 1 could be used as an effective fluorescent probe for detecting HOCl in living cells.",

keywords = "Biological imaging, Flourescent probe, Fluorescein, Hypochlorite anion, Spirolactam, Water solubility",

author = "Wenzhu Yin and Hongjun Zhu and Ruiyong Wang",

year = "2014",

month = aug,

doi = "10.1016/j.dyepig.2014.03.012",

language = "英语",

volume = "107",

pages = "127--132",

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AU - Yin, Wenzhu

AU - Zhu, Hongjun

AU - Wang, Ruiyong

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Y1 - 2014/8

N2 - A highly sensitive and selective fluorescein-based probe 1 for hypochlorite anion was synthesized. The probe 1 has favorable characteristics for biological imaging, including high water solubility, high fluorescence yield, pH-independent fluorescence, and biocompatibility. Results show that it has a detection limit of 40 nM to hypochlorite anion. In addition, confocal fluorescence microscopy imaging using RAW264.7 cells showed that the new probe 1 could be used as an effective fluorescent probe for detecting HOCl in living cells.

AB - A highly sensitive and selective fluorescein-based probe 1 for hypochlorite anion was synthesized. The probe 1 has favorable characteristics for biological imaging, including high water solubility, high fluorescence yield, pH-independent fluorescence, and biocompatibility. Results show that it has a detection limit of 40 nM to hypochlorite anion. In addition, confocal fluorescence microscopy imaging using RAW264.7 cells showed that the new probe 1 could be used as an effective fluorescent probe for detecting HOCl in living cells.

KW - Biological imaging

KW - Flourescent probe

KW - Fluorescein

KW - Hypochlorite anion

KW - Spirolactam

KW - Water solubility

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SN - 0143-7208

VL - 107

SP - 127

EP - 132

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

A sensitive and selective fluorescence probe based fluorescein for detection of hypochlorous acid and its application for biological imaging

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