Lipid-regulating and anti-atherosclerosis effects of α-amylase inhibitor extracted from wheat

Aim: To study the lipid-regulating and anti-atherosclerosis effects of α-amylase inhibitor. Methods: In the prevention study, the rats were raised with high fat diet for 9 weeks and co-administered with various doses of α-amylase inhibitor. The concentration of TC, TG, HDL-C, LDL-C, MDA, SOD in serum as well as TC, TG in liver were assayed the 63rd day. Meanwhile, the impacts to hepatic hemorheology, pathology and artery were also examined. In the therapeutic study, affer the rats were raised with high fat diet for successive 3 weeks, they were administered with various doses of α-amylase inhibitor for the next 3 weeks. The levels of TC, TG, HDL-C, LDL-C in serum and TC, TG in liver were determined in the 42nd day. Results: In the prevention study, α-amylase inhibitor of the middle and high doses could markedly decrease the concentration of TC, TG, LDL-C and MDA in serum as well as TC, TG in liver. It increased the level of HDL-C and the activity of SOD. The treatment also resulted in improvement in hepatic hemorheology, pathology and artery. In the therapeutic study, α-amylase inhibitor of the high doses could significantly reduce the concentration of TC, TG and LDL-C in serum as well as TC, TG in liver. But the treatment increased the concentration of HDL-C in serum. Conclusion: α-amylase inhibitor could regulate blood lipid, prevent hyperlipidemia and atherosclerosis. It also has certain effects on formed hyperlipemia.