Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

Yu Cai; Weili Si; Qianyun Tang; Pingping Liang; Chengwu Zhang; Peng Chen; Qi Zhang; Wei Huang; Xiaochen Dong

doi:10.1007/s12274-016-1332-2

Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

Yu Cai, Weili Si, Qianyun Tang, Pingping Liang, Chengwu Zhang, Peng Chen, Qi Zhang, Wei Huang, Xiaochen Dong

科研成果: 期刊稿件 › 文章 › 同行评审

55 引用（Scopus）

摘要

Therapeutic nanoparticles (NPs) based on the donor–acceptor–donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm^‒2), even at a low dose (0.16 mg·kg^‒1). [Figure not available: see fulltext.]

源语言	英语
页（从-至）	794-801
页数	8
期刊	Nano Research
卷	10
期	3
DOI	https://doi.org/10.1007/s12274-016-1332-2
出版状态	已出版 - 1 3月 2017

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Cai, Y., Si, W., Tang, Q., Liang, P., Zhang, C., Chen, P., Zhang, Q., Huang, W., & Dong, X. (2017). Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy. Nano Research, 10(3), 794-801. https://doi.org/10.1007/s12274-016-1332-2

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title = "Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy",

abstract = "Therapeutic nanoparticles (NPs) based on the donor–acceptor–donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm‒2), even at a low dose (0.16 mg·kg‒1). [Figure not available: see fulltext.]",

keywords = "diketopyrrolopyrrole, donor–acceptor–donor, photoacoustic imaging, photothermal therapy",

author = "Yu Cai and Weili Si and Qianyun Tang and Pingping Liang and Chengwu Zhang and Peng Chen and Qi Zhang and Wei Huang and Xiaochen Dong",

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T1 - Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

AU - Cai, Yu

AU - Si, Weili

AU - Tang, Qianyun

AU - Liang, Pingping

AU - Zhang, Chengwu

AU - Chen, Peng

AU - Zhang, Qi

AU - Huang, Wei

AU - Dong, Xiaochen

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Therapeutic nanoparticles (NPs) based on the donor–acceptor–donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm‒2), even at a low dose (0.16 mg·kg‒1). [Figure not available: see fulltext.]

AB - Therapeutic nanoparticles (NPs) based on the donor–acceptor–donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm‒2), even at a low dose (0.16 mg·kg‒1). [Figure not available: see fulltext.]

KW - diketopyrrolopyrrole

KW - donor–acceptor–donor

KW - photoacoustic imaging

KW - photothermal therapy

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U2 - 10.1007/s12274-016-1332-2

DO - 10.1007/s12274-016-1332-2

M3 - 文章

AN - SCOPUS:85006856372

SN - 1998-0124

VL - 10

SP - 794

EP - 801

JO - Nano Research

JF - Nano Research

IS - 3

ER -

Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

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