TY - JOUR
T1 - Solid-Liquid Phase Equilibrium and Thermodynamic Properties of Olaparib in Selected Organic Solvents and (Tetrahydrofuran + MTBE, Acetonitrile + Isopropyl Alcohol) Binary Solvent Mixtures
AU - Zhao, Wangdan
AU - Yang, Wenge
AU - Zhang, Jian
AU - Sheng, Huace
AU - Zhao, Xinxin
AU - Hu, Yonghong
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/11/9
Y1 - 2017/11/9
N2 - We focused on the solubility of olaparib under atmospheric pressure in isopropyl alcohol, MTBE, acetonitrile, and tetrahydrofuran as well as in the (tetrahydrofuran + MTBE, acetonitrile + isopropyl alcohol) mixtures from 280.35-319.35 K. It is found that the solubility of olaparib and temperature were positively correlated in the range of our study. We chose the modified Apelblat equation, the Buchowski-Ksiazaczak λh equation, CNIBS/R-K equation, and the Jouyban-Acree equation to verify the thermodynamic properties of olaparib. Computational results showed that all selected equations agreed well with the experimental data, and the modified Apelblat equation gives the best correlation. We also selected two binary solvent dissolution systems, and the test found that (tetrahydrofuran + MTBE) mixtures may be a good recrystallization system. This study provides valuable data for olaparib's production process purification.
AB - We focused on the solubility of olaparib under atmospheric pressure in isopropyl alcohol, MTBE, acetonitrile, and tetrahydrofuran as well as in the (tetrahydrofuran + MTBE, acetonitrile + isopropyl alcohol) mixtures from 280.35-319.35 K. It is found that the solubility of olaparib and temperature were positively correlated in the range of our study. We chose the modified Apelblat equation, the Buchowski-Ksiazaczak λh equation, CNIBS/R-K equation, and the Jouyban-Acree equation to verify the thermodynamic properties of olaparib. Computational results showed that all selected equations agreed well with the experimental data, and the modified Apelblat equation gives the best correlation. We also selected two binary solvent dissolution systems, and the test found that (tetrahydrofuran + MTBE) mixtures may be a good recrystallization system. This study provides valuable data for olaparib's production process purification.
UR - http://www.scopus.com/inward/record.url?scp=85033601992&partnerID=8YFLogxK
U2 - 10.1021/acs.jced.7b00489
DO - 10.1021/acs.jced.7b00489
M3 - 文章
AN - SCOPUS:85033601992
SN - 0021-9568
VL - 62
SP - 3744
EP - 3752
JO - Journal of Chemical and Engineering Data
JF - Journal of Chemical and Engineering Data
IS - 11
ER -