Solubility of 1-(3-bromopropoxy)-4-chlorobenzene in aqueous ethanol mixtures from (273.15 to 303.15) K

1-(3-Bromopropoxy)-4-chlorobenzene is an important intermediate for the manufacture of omoconazole nitrate. The solubilities of 1-(3-bromopropoxy)-4- chlorobenzene in aqueous ethanol solutions were measured within the temperature range of (273.15-303.15) K using a laser monitoring system. For the temperature range investigated, the solubilities of 1-(3-bromopropoxy)-4-chlorobenzene in the aqueous ethanol mixtures increase with increasing temperature. The solubility data were regressed by the Buchowski-Ksiazaczak λh and the modified Apelblat models. The modified Apelblat equation and the Buchowski-Ksiazaczak λh equation provided accurate mathematical representations of the experimental results. The calculated solubilities showed good agreement with the experimental data. The root-mean-square deviations of the modified Apelblat model were lower than those of the Buchowski-Ksiazaczak λh model. This study provided valuable data for the purification of 1-(3-bromopropoxy)-4-chlorobenzene by crystallization.