TY - CHAP
T1 - The effects of strontium on physiology, pharmacology and toxicity of the human
AU - Ying, Hanjie
AU - Zhang, Qi
AU - Ma, Bo
PY - 2013/1
Y1 - 2013/1
N2 - Strontium (Sr) is one of the most extensively investigated alkaline earth metals and has been received much attention for biomedical applications since strontium ranelate was marked as a new orally administered agent for the treatment of women with postmenopausal osteoporosis that reduces the risk of vertebral and nonvertebral fractures by Servier Laboratories. In this review, we have summarised its physical and chemical properties, applications, and biological role on human health, including characteristics, isotopes, effect on the human body in nutrition, toxicity and general physiology, calcium-strontium interactions, absorption and transport, and strontium salts used as medicines. The promoting action of strontium on calcium uptake into bone at moderate strontium supplementation, applications and mechanism of anti-osteoporosis by inhibiting bone resorption by osteoclasts and promoting osteoblast replication and bone formation, the rachitogenic action and rickets of strontium at higher dietary strontium levels and more recent publications relevant to medicine are also described.
AB - Strontium (Sr) is one of the most extensively investigated alkaline earth metals and has been received much attention for biomedical applications since strontium ranelate was marked as a new orally administered agent for the treatment of women with postmenopausal osteoporosis that reduces the risk of vertebral and nonvertebral fractures by Servier Laboratories. In this review, we have summarised its physical and chemical properties, applications, and biological role on human health, including characteristics, isotopes, effect on the human body in nutrition, toxicity and general physiology, calcium-strontium interactions, absorption and transport, and strontium salts used as medicines. The promoting action of strontium on calcium uptake into bone at moderate strontium supplementation, applications and mechanism of anti-osteoporosis by inhibiting bone resorption by osteoclasts and promoting osteoblast replication and bone formation, the rachitogenic action and rickets of strontium at higher dietary strontium levels and more recent publications relevant to medicine are also described.
UR - http://www.scopus.com/inward/record.url?scp=84891976772&partnerID=8YFLogxK
M3 - 章节
AN - SCOPUS:84891976772
SN - 9781622576319
SP - 1
EP - 25
BT - Strontium
PB - Nova Science Publishers, Inc.
ER -
