Thermodynamic Models for Determination of Solid-Liquid Equilibrium of the Sarafloxacin Hydrochloride in Pure and Binary Organic Solvents from (278.15 to 333.15) K

Meng Cheng, Xin Zhao, Aixiang Hao, Wenhao Jiao, Wenge Yang, Yonghong Hu

科研成果: 期刊稿件文章同行评审

5 引用 (Scopus)

摘要

In this study, the gravimetric method was taken to measure the solubility of the sarafloxacin hydrochloride under atmospheric pressure in methanol, isopropanol, ethanol, 1-butanol, acetonitrile, n-hexane, ethyl acetate, and N,N-dimethylformamide as well as in the (ethyl acetate + acetonitrile), (methanol + n-hexane), and (ethyl acetate + n-hexane) mixtures from 278.15 to 333.15 K. The solubility of sarafloxacin hydrochloride increased with increasing temperature in all the solvents. The solid-liquid solubility equilibrium data in the pure and mixed solvents were in apparent agreement with the solubility predicted by the modified Apelblat model, Buchowski-Ksiazaczak λh model, Redlich-Kister (CNIBS/R-K) model, and Jouyban-Acree model. However, the Redlich-Kister (CNIBS/R-K) model best simulated the experimental solubility results.

源语言英语
页(从-至)4869-4880
页数12
期刊Journal of Chemical and Engineering Data
65
10
DOI
出版状态已出版 - 8 10月 2020

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