Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes

Zheng Li Liu; Chao Yang; Qi Yan Xue; Meng Zhao; Cui Cui Shan; Yun He Xu; Teck Peng Loh

doi:10.1002/anie.201908343

Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes

Zheng Li Liu, Chao Yang, Qi Yan Xue, Meng Zhao, Cui Cui Shan, Yun He Xu, Teck Peng Loh

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

A copper-catalyzed silylation of propargyl dichlorides was developed to access chloro-substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro-substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol.

Original language	English
Pages (from-to)	16538-16542
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	58
Issue number	46
DOIs	https://doi.org/10.1002/anie.201908343
State	Published - 11 Nov 2019
Externally published	Yes

Keywords

allenes
copper
enantioselectivity
silanes
synthetic methods

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10.1002/anie.201908343

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title = "Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes",

abstract = "A copper-catalyzed silylation of propargyl dichlorides was developed to access chloro-substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro-substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol.",

keywords = "allenes, copper, enantioselectivity, silanes, synthetic methods",

author = "Liu, {Zheng Li} and Chao Yang and Xue, {Qi Yan} and Meng Zhao and Shan, {Cui Cui} and Xu, {Yun He} and Loh, {Teck Peng}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.",

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T1 - Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides

T2 - Access to Enantioenriched Functionalized Allenylsilanes

AU - Liu, Zheng Li

AU - Yang, Chao

AU - Xue, Qi Yan

AU - Zhao, Meng

AU - Shan, Cui Cui

AU - Xu, Yun He

AU - Loh, Teck Peng

PY - 2019/11/11

Y1 - 2019/11/11

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AB - A copper-catalyzed silylation of propargyl dichlorides was developed to access chloro-substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro-substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol.

KW - allenes

KW - copper

KW - enantioselectivity

KW - silanes

KW - synthetic methods

UR - http://www.scopus.com/inward/record.url?scp=85074368530&partnerID=8YFLogxK

U2 - 10.1002/anie.201908343

DO - 10.1002/anie.201908343

M3 - 文章

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AN - SCOPUS:85074368530

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JO - Angewandte Chemie - International Edition

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ER -

Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes

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Keywords

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