Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes

Zheng Li Liu, Chao Yang, Qi Yan Xue, Meng Zhao, Cui Cui Shan, Yun He Xu, Teck Peng Loh

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

A copper-catalyzed silylation of propargyl dichlorides was developed to access chloro-substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro-substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol.

Original languageEnglish
Pages (from-to)16538-16542
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number46
DOIs
StatePublished - 11 Nov 2019
Externally publishedYes

Keywords

  • allenes
  • copper
  • enantioselectivity
  • silanes
  • synthetic methods

Fingerprint

Dive into the research topics of 'Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes'. Together they form a unique fingerprint.

Cite this