Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

Xue Qiang Chu; Bu Qing Cheng; Yao Wei Zhang; Danhua Ge; Zhi Liang Shen; Teck Peng Loh

doi:10.1039/c7cc09571f

Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

Xue Qiang Chu, Bu Qing Cheng, Yao Wei Zhang, Danhua Ge, Zhi Liang Shen, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.

Original language	English
Pages (from-to)	2615-2618
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	21
DOIs	https://doi.org/10.1039/c7cc09571f
State	Published - 2018

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title = "Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines",

abstract = "An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.",

author = "Chu, {Xue Qiang} and Cheng, {Bu Qing} and Zhang, {Yao Wei} and Danhua Ge and Shen, {Zhi Liang} and Loh, {Teck Peng}",

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T1 - Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

AU - Chu, Xue Qiang

AU - Cheng, Bu Qing

AU - Zhang, Yao Wei

AU - Ge, Danhua

AU - Shen, Zhi Liang

AU - Loh, Teck Peng

PY - 2018

Y1 - 2018

N2 - An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.

AB - An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.

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U2 - 10.1039/c7cc09571f

DO - 10.1039/c7cc09571f

M3 - 文章

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AN - SCOPUS:85043462725

SN - 1359-7345

VL - 54

SP - 2615

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JO - Chemical Communications

JF - Chemical Communications

IS - 21

ER -

Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

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