Abstract
In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging-guided tumor chemotherapy in living mice.
| Original language | English |
|---|---|
| Pages (from-to) | 5063-5069 |
| Number of pages | 7 |
| Journal | Advanced Materials |
| Volume | 27 |
| Issue number | 34 |
| DOIs | |
| State | Published - 1 Sep 2015 |
| Externally published | Yes |
Keywords
- drug delivery
- melanin nanoparticles
- photoacoustic imaging
- positron emission tomography (PET)
- sorafenib