Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds

Xuan Yu Liu; Xiang Rui Li; Chen Zhang; Xue Qiang Chu; Weidong Rao; Teck Peng Loh; Zhi Liang Shen

doi:10.1021/acs.orglett.9b01999

Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds

Xuan Yu Liu, Xiang Rui Li, Chen Zhang, Xue Qiang Chu, Weidong Rao, Teck Peng Loh, Zhi Liang Shen

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.

Original language	English
Pages (from-to)	5873-5878
Number of pages	6
Journal	Organic Letters
Volume	21
Issue number	15
DOIs	https://doi.org/10.1021/acs.orglett.9b01999
State	Published - 2 Aug 2019

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title = "Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds",

abstract = "An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.",

author = "Liu, {Xuan Yu} and Li, {Xiang Rui} and Chen Zhang and Chu, {Xue Qiang} and Weidong Rao and Loh, {Teck Peng} and Shen, {Zhi Liang}",

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T1 - Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds

AU - Liu, Xuan Yu

AU - Li, Xiang Rui

AU - Zhang, Chen

AU - Chu, Xue Qiang

AU - Rao, Weidong

AU - Loh, Teck Peng

AU - Shen, Zhi Liang

PY - 2019/8/2

Y1 - 2019/8/2

N2 - An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.

AB - An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.

UR - http://www.scopus.com/inward/record.url?scp=85070705146&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.9b01999

DO - 10.1021/acs.orglett.9b01999

M3 - 文章

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AN - SCOPUS:85070705146

SN - 1523-7060

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SP - 5873

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JO - Organic Letters

JF - Organic Letters

IS - 15

ER -

Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds

Abstract

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