Abstract
An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.
Original language | English |
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Pages (from-to) | 5873-5878 |
Number of pages | 6 |
Journal | Organic Letters |
Volume | 21 |
Issue number | 15 |
DOIs | |
State | Published - 2 Aug 2019 |