Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds

Xuan Yu Liu, Xiang Rui Li, Chen Zhang, Xue Qiang Chu, Weidong Rao, Teck Peng Loh, Zhi Liang Shen

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.

Original languageEnglish
Pages (from-to)5873-5878
Number of pages6
JournalOrganic Letters
Volume21
Issue number15
DOIs
StatePublished - 2 Aug 2019

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