Abstract
A transition-metal-free multi-functionalization reaction of β-trifluoromethyl enones and azacycles is first developed for the synthesis of valuable amino-2,3-dihydrofuran derivatives in moderate to good yields with excellent functional group tolerance. The multi-functionality transformation of carbonyl, alkenyl, and trifluoromethyl groups in β-trifluoromethyl enones streamlines the five-membered O-heterocycle assembly and facilitates the multiple-bond-forming cascade, thus providing a novel reaction mode for the defluorinative utilization of β-CF3-enones.
Original language | English |
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Pages (from-to) | 5144-5150 |
Number of pages | 7 |
Journal | Organic Chemistry Frontiers |
Volume | 11 |
Issue number | 18 |
DOIs | |
State | Published - 25 Jul 2024 |