Multi-functionalization of β-trifluoromethyl enones enabled 2,3-dihydrofuran synthesis

Ya Fei Hu, Wei Han, Ye Kun Chen, Mengtao Ma, Zhi Liang Shen, Xue Qiang Chu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A transition-metal-free multi-functionalization reaction of β-trifluoromethyl enones and azacycles is first developed for the synthesis of valuable amino-2,3-dihydrofuran derivatives in moderate to good yields with excellent functional group tolerance. The multi-functionality transformation of carbonyl, alkenyl, and trifluoromethyl groups in β-trifluoromethyl enones streamlines the five-membered O-heterocycle assembly and facilitates the multiple-bond-forming cascade, thus providing a novel reaction mode for the defluorinative utilization of β-CF3-enones.

Original languageEnglish
Pages (from-to)5144-5150
Number of pages7
JournalOrganic Chemistry Frontiers
Volume11
Issue number18
DOIs
StatePublished - 25 Jul 2024

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