Multi-functionalization of β-trifluoromethyl enones enabled 2,3-dihydrofuran synthesis

A transition-metal-free multi-functionalization reaction of β-trifluoromethyl enones and azacycles is first developed for the synthesis of valuable amino-2,3-dihydrofuran derivatives in moderate to good yields with excellent functional group tolerance. The multi-functionality transformation of carbonyl, alkenyl, and trifluoromethyl groups in β-trifluoromethyl enones streamlines the five-membered O-heterocycle assembly and facilitates the multiple-bond-forming cascade, thus providing a novel reaction mode for the defluorinative utilization of β-CF₃-enones.