Palladium-Catalyzed Regioselective Olefination of O-Acetyl Cyanohydrins

Qiu Ju Liang; Bing Jiang; Yun He Xu; Teck Peng Loh

doi:10.1021/acs.joc.8b00991

Palladium-Catalyzed Regioselective Olefination of O-Acetyl Cyanohydrins

Qiu Ju Liang, Bing Jiang, Yun He Xu, Teck Peng Loh

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.

Original language	English
Pages (from-to)	8265-8271
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	83
Issue number	15
DOIs	https://doi.org/10.1021/acs.joc.8b00991
State	Published - 3 Aug 2018
Externally published	Yes

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title = "Palladium-Catalyzed Regioselective Olefination of O-Acetyl Cyanohydrins",

abstract = "A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.",

author = "Liang, {Qiu Ju} and Bing Jiang and Xu, {Yun He} and Loh, {Teck Peng}",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

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doi = "10.1021/acs.joc.8b00991",

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AU - Liang, Qiu Ju

AU - Jiang, Bing

AU - Xu, Yun He

AU - Loh, Teck Peng

PY - 2018/8/3

Y1 - 2018/8/3

N2 - A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.

AB - A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.

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U2 - 10.1021/acs.joc.8b00991

DO - 10.1021/acs.joc.8b00991

M3 - 文章

C2 - 29902382

AN - SCOPUS:85048668406

SN - 0022-3263

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SP - 8265

EP - 8271

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 15

ER -

Palladium-Catalyzed Regioselective Olefination of O-Acetyl Cyanohydrins

Abstract

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