A double-indole structure fluorescent probe for monitoring sulfur dioxide derivatives with distinct ratiometric fluorescence signals in mammalian cells

Li Wang, Wenge Yang, Yiyi Song, Yuanyun Gu, Yonghong Hu

科研成果: 期刊稿件文章同行评审

14 引用 (Scopus)

摘要

Based on the addition reaction of the sulfur dioxide derivative to the C[dbnd]C double bond, the probe HDI was designed and synthesized. The two-channel fluorescent probe HDI changed from orange to colorless and the fluorescence changed from red to blue when the bisulfite was detected. And the probe responds rapidly to bisulfite within 2 min, with high sensitivity and specificity. In addition, the probe can be used to detect the concentration of bisulfite with a low detection limit (80 nM). Cytological experiments have also demonstrated that probe HDI has low cytotoxicity and could be used for ratiometric detection of sulfur dioxide derivatives in living cells.

源语言英语
文章编号117495
期刊Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
225
DOI
出版状态已出版 - 15 1月 2020

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